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Localized Scleroderma is a rare autoimmune connective tissue disorder (CTD) that leads to inflammation and thickening of the skin.

Localized Scleroderma causes excessive collagen deposition that may be disfiguring and can cover joints and cause pain and affect mobility and quality of life. About 90,000 people in the U.S. are living with Localized Scleroderma, and there are more than two million people affected globally.